http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102021001917-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f323d7ac3baf8d55e4c5e7c5aaa3fee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e21d9f27207904d54852ca4082604ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7db38bc4178721c1e2a345df3361ea4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-616 |
| filingDate | 2021-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc23b0c318d12b4c829a757aa01bbaa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ea2d663c64a6022616043a11e12c4a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b06189b7287bceba172e0fc294002580 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_787dd6c150a10d2629f5701b2ce8c487 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e201bf645f4863a777e9282d7a1cc7b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad76016c2d3527c5cb590e8c9563c0ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8713acf7a2dc3e11e3d0ee483bd5a478 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60231decde13128200ea5d83b0df81e8 |
| publicationDate | 2022-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102021001917-A2 |
| titleOfInvention | APPLICATION OF KETO-SALICYLATE DERIVATIVES IN INFLAMMATION, ANALGESIA AND PLATELET AGGREGATION OBTAINED BY THE MOLECULAR TRANSFORMATION OF SALICYLATE ESTERS |
| abstract | APPLICATION OF KETO-SALICYLATES DERIVATIVES IN INFLAMMATION, ANALGESIA AND PLATELET AGGREGATION OBTAINED BY THE MOLECULAR TRANSFORMATION OF SALICYLATE ESTERS. The present invention relates to the application of derivatives of the molecular transformation of ester derivatives of salicylates into keto-salicylates as anti-inflammatory, analgesic and antiplatelet agents and cyclooxygenase 2 (COX-2) inhibitors. Aspirin homologues, modified in the ester group, showed that the increase in the acyl group alters the affinity for the COX isoenzymes. The proposed compounds were designed from salicylate esters evaluated on the COX-1 enzymatic isoform, which is constitutive notably known for its ulcerogenic action. The proposed strategy for molecular modification was based on the classical Friedel-Crafts reaction. The results obtained showed that the increase of the homologous chain in ester and ketone groups can generate more promising derivatives of salicylates, which can be selective for the COX-2 enzyme and that ketone derivatives are more promising than ester derivatives. |
| priorityDate | 2021-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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