http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102020021653-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d71f4d06c9a84c3b0d6f69d842a84175 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
| filingDate | 2020-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa338d9e2199f31c537c502708953b10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44375c8a56dd88f063585f2e14550436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50d95a06937205b03113d37937ced2e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_473f39681b842d6d8230d3dbf9488218 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66b67fa4cfff47a9ddadd61c2f1f98c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5137ef8a784e94085f3c832f15d66c3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ca32a639dbc1a45f982eb48747f4ff1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8540dda4811a5699000e3cb60371964 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43057fa9afdcfda1fcf501c0b9690717 |
| publicationDate | 2022-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102020021653-A2 |
| titleOfInvention | Bignelli compounds against multiresistant bacteria to conventional antibacterials |
| abstract | bignelli compounds against multiresistant bacteria to conventional antibacterials. the invention relates to analogues of dihydropyrimidinones, substituted in the c-4 position of the aromatic aldehyde (4-methoxyphenyl, 4-chlorophenyl and p-toluyl), which have the nomenclatures: 6-methyl-2-oxo-4-(4 ethyl -chlorophenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate; Ethyl 6-methyl-2-oxo-4-(p-toluyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate and 6-methyl-2-oxo-4-(4-methoxyphenyl)-1, ethyl 2,3,4-tetrahydropyrimidine-5-carboxylate. these synthetic compounds have antibacterial properties against gram-positive cocci (staphylococcus aureus and enterococcus faecium) and gram-negative bacilli (escherichia coli, enterobacter cloacae, klebsiella pneumoniae, morganella morgannii and serratia marcescens) multiresistant against conventional antibiotics, showing potential for use as antimicrobial agents. the dihydropyrimidinones were synthesized in the lipidomics and bio-organic laboratory and tested in the microbiology and parasitology laboratory of the institute of biology of the federal university of pelotas, rs-basil. the increase in bacterial resistance to antibiotics has led to high rates of morbidity and mortality, configuring a serious public health problem through the lack of efficient measures in the control and prevention of infections and the evolution and natural adaptation of bacteria by mutations and genetic recombinations caused by the indiscriminate use of antibiotics, requiring investments and research into new drugs. |
| priorityDate | 2020-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.