http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102020021058-A8
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f861d7dfdde7b233339d4838364a8e8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-66 |
| filingDate | 2020-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59ab1462052820aff57cb2b8be8271cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_890b624def5f58d2473ae68a183e8950 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a8ad61a55144eb0d1a65ef7dad66d99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93bc91a921d4b2106fe3c17c0f2f8e0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed873eef260560d7203368071fd4137d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_934d394ac867d47148308cb7d12ec5cd |
| publicationDate | 2022-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102020021058-A8 |
| titleOfInvention | Memantine prodrugs for extended transdermal release, pharmaceutical compositions and uses |
| abstract | memantine prodrugs for transdermal sustained release, pharmaceutical compositions and uses. the present technology relates to prodrugs that allow prolonged transdermal drug delivery. prodrugs are formed by obtaining schiff bases from memantine with the carbonyl group of another molecule. the hydrolysis of these bases allows altering the drug release time. in addition to the schiff bases formed between memantine and drugs or bioactive molecules, prodrugs can comprise metal complexes that can be used as an additional modulation of the release of the active ingredient. as an embodiment of the present technology, it presents a conjugated prodrug of memantine and pyridoxal (vitamin b6) and its metal complexes of zinc(ii) and copper(ii); and conjugated prodrugs of memantine with haloperidol and other butyrophenones, such as spiperone. the technology also relates to pharmaceutical compositions containing said prodrugs and their use to prepare medicaments for the treatment of neurodegenerative diseases, such as Alzheimer's disease and schizophrenia. |
| priorityDate | 2020-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.