http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102019021619-A2

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filingDate 2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3dfef86d136e675e714bc98d9952f76
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publicationDate 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-102019021619-A2
titleOfInvention BIOMATERIAL WITH BACTERIOSTATIC AND BACTERICIDE ACTIVITY FOR BONE AND DENTAL REGENERATION
abstract The patent application in question refers to the compositions of vitreous materials (prepared by the melting / cooling method) and vitroceramics (synthesized via controlled crystallization depending on the heat treatment time) of the borate family, which contains: boron , phosphorus, calcium, sodium and silver. These materials, when immersed in simulated physiological fluid, promote the formation of Apatite (HA and FA), characterizing the bioactivity of the material developed. These compositions present Silver Oxide (Ag2O) as a network modifier, bactericidal and bacteriostatic agent, and crystallizing agent. During the heat treatment in the glassy samples, a crystalline microstructure develops. The different percentages of crystallinity allow to control the rate of dissolution / conversion to apatite of the material, without compromising its bioactive behavior. Ag + ions in a biological environment have antibacterial and non-cytotoxic properties. Therefore, the reported biomaterial has important characteristics for potential application as biomaterials, such as its bioactivity, bactericidal and bacteriostatic action, without causing adverse reactions in the body, being indicated for applications in bone and dental restoration in the form of bulk, powder, composites, fibers, tubes, plates, screws and / or pins for implants.
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