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publicationDate 2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-102019020328-A2
titleOfInvention hybrid compounds (2-cyano-3- (indole-3-yl) -n-phenylacrylamide with immunomodulatory, anti-inflammatory and analgesic potential
abstract hybrid compounds (2-cyano-3- (indole-3-yl) -n-phenylacrylamide derived from paracetamol and indomethacin with potential immunomodulatory, anti-inflammatory and analgesic potential.The present invention relates to a composition in the field of medicinal chemistry and these are hybrid compounds (2-cyano-3- (indole-3-yl) -n-phenylacrylamide derived from paracetamol and indomethacin with potential immunomodulatory, anti-inflammatory and analgesic potential. fbdd (fragment besid drug design) by means of an amidation reaction between substituted anilines and ethyl 2-cyanoacetate, followed by a knovenagel condensation reaction with different substituted indole aldehydes.
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