http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102019018181-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c592588ed01bff7438d31b476c7b14fd |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-14 |
| filingDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f9b9adc0844cf85f95bdeb391ee24e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d68ba47e33215204cf48019fbd72af2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_479ff805a0971d3352efa0d1a168f02d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f149eaf24f17ee7c0fa93f3bde7acf1 |
| publicationDate | 2021-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102019018181-A2 |
| titleOfInvention | ENHYZE ACETYL CHOLINESTERASE ACTIVITY INHIBITING COMPOUNDS |
| abstract | COMPOUNDS INHIBITORS OF THE ACTIVITY OF THE ENZYM ACETYL CHOLINESTERASE, the present invention belongs to the field of organic chemistry, specifically organic synthesis, its process of obtaining involves the synthesis of a new class of compounds derived from the BTD nucleus and its application in the inhibition of the activity of the enzyme acetylcholinesterase aiming at new therapeutic possibilities for the treatment of Alzheimer's disease, the methodology used for the synthesis of the compounds using the Pd [(L) -proline] 2 catalyst is simple, highly efficient and the biological tests for inhibition of the enzyme acetylcholinesterase showed excellent results for several compounds, demonstrating the potential of this class as an anticholinesterase agent, thus, a comprehensive analysis of the data obtained with the arylsulfanyl-benzothiadiazole compounds reveals that there is a structure-activity relationship that may be useful in the search for new therapeutic agents for application in the treatment of Alzheimer's disease. |
| priorityDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 167.