| abstract |
Malaria is a parasitic disease that affects a large part of the world population. In the absence of an effective vaccine, its treatment depends on the use of chemotherapeutic drugs and the need for new treatments is reinforced by the growing resistance identified to current antimalarials. Thus, the present study aimed to evaluate the in vitro antimalarial activity of the compounds against the P. falciparum (W2) strain. For that, Clioquinol was tested using the traditional test. In addition, the cytotoxicity assay was performed using the WI-26VA4 cell line by the MTT test to verify cell viability. Experimentally it was found that it does not present cytotoxicity, with IC50> 100. Thus, the results suggest that these compounds can be used as antimalarials. The present invention demonstrates Clioquinol (5-Chloro-7-iodo-8-quinolinol, 5-Chloro-8-hydroxy-7-iodoquinoline, Clioquinol, Iodochlorhydroxyquin) as an antimalarial agent. |