http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102018008561-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8b3186ebe6d5d35e4aff2ab3437c5fc |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0793 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B25-10 |
| filingDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0d7651946591e2351f08744f4a236f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dec025c920b000e660f5cbb716f683a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8c4f41435f4c3c1049f5016c9a3f3ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d086c4844cdcdebf3070356272b4566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47ae53d6b76c53a7e4a942f5441dbfcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_654b9307552b9609f3f8b65517c05feb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7adcf6723b125f2da5b576ebe68148f |
| publicationDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102018008561-A2 |
| titleOfInvention | process and kit to identify molecular entities involved in osteoarthritis pain |
| abstract | The method and kit for identifying molecular entities involved in osteoarthritis pain The present invention is in the fields of biochemistry, pharmacology, immunology, and drug development. More specifically, the invention provides an in vitro process for identifying molecular entities, such as effective therapeutic agents and / or molecular targets for drug development, for the control of chronic osteoarthritis (oa) pain. The process of the invention comprises the following steps: (i) In vitro incubation of neurons with at least one compound to stimulate inflammation, followed by (ii) analysis of a gene panel associated with pain transduction, pain transmission and / or modulation of pain responses, and (iii) correlation of the gene expression profile obtained in the previous step with oa pain and / or oa-associated inflammatory condition. In one embodiment, the process of the invention provides for in vitro interaction between chemically modified collagen and neurons derived from human cell line (s) in order to reproduce one of the early inflammatory events involved in pain genesis observed in oa. The process of the invention provides for the identification of effective therapeutic agents and / or molecular targets for drug development to control chronic pain in oa. |
| priorityDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 865.