| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d6eb785a13032f52d1f7f654acac96d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 |
| filingDate |
2018-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8124bafcdb58a06cf1a50a1ea4392802
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58df55eaac049d974aea09ad22dc5004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af9a57487f49c4f793e6fe9d1ec34aee |
| publicationDate |
2019-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-102018001033-A2 |
| titleOfInvention |
ASPARAGINASE ACTIVITY POLYPEPTIDE, EXPRESSION CASSETTE, EXPRESSION VECTOR, HOST CELL, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCING AN ASPARAGINASE ACTIVITY AND FOR PREVENTING OR TREATING, AND CANCERING, CANCER. |
| abstract |
The present invention relates to asparaginase activity polypeptides that have increased self-processing rate compared to wild human 1-asparaginase (asrgl1), with mutation in the asrgl1 glycine rich loop called hgg loop (histidine 8-glycine 9-glycine 10 ). Also described herein are polynucleotides encoding the polypeptides of the invention, expression cassettes comprising said polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the polypeptide of the invention in the manufacture of a cancer prevention or treatment medicament and methods for producing the polypeptide of the invention and to prevent or treat cancer. |
| priorityDate |
2018-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |