http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102017020980-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d7dc0431b7317ecccd046a5a50d385f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_849830a112ea3057458bb0e4bb260e4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_254bae8d3624c49bc040aa0f743fbdb6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c32711b766f085e42ca0bbd67f4bb5e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93cb837c123d3ebdfa38ea60131fe1bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b4b758f1a891229ccbc0fb70327d7b1 |
| publicationDate | 2019-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102017020980-A2 |
| titleOfInvention | AFLATOXINE MIMETIC PEPTIDIC SEQUENCE APPLIED AS IMMUNOGEN |
| abstract | The present invention relates to the technical field of biotechnology and is characterized by the amino acid sequence qtdldylhplinswn capable of inducing the production of specific antibodies that recognize aflatoxin b1. In order to replace aflatoxin conjugates in immunizations and to propose a toxin immunization model, the mimotope-based immunogen, i.e. aflatoxin mimetic peptide expressed on the surface of bacteriophages, was obtained. The recombinant bacteriophage 3p30 was selected by the phage display technique (Fig. 1, 2 and 3) and exhibited specific binding ability to its cognate target, anti-afb1 antibody (Fig. 4), when compared to irrelevant ligands (Fig. 5). ), demonstrating dose dependent profile (Fig. 6). In immunization assay, the phage-expressed mimotope and chemically synthesized peptide were able to induce aflatoxin-recognizing anti-peptide antibodies (Fig. 7). This strategy proves the mimicry between the peptide and the toxin, allowing the application of the aflatoxin mimetic peptide for vaccine development. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110615831-A |
| priorityDate | 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.