http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102017010928-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b77cf72a804dcf3e755b61960d1fdc4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63ff5fb2174de68979f3a2c778d833a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44b1b897b3d0389a92e946761ad8ef57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ad877af48568570de6a9780419497b3 |
| publicationDate | 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102017010928-A2 |
| titleOfInvention | production process of bovine albumin nanoparticles containing amphotericin b and coated with polysorbate 80 by the coacervation method |
| abstract | production process of bovine albumin nanoparticles containing amphotericin b and coated with polysorbate 80 by the coacervation method. The present invention comprises the process of producing amphotericin B-containing bovine albumin nanoparticles coated with polysorbate 80 by the coacervation method as an alternative strategy for drug carrier. This invention provides the development of nanoparticles with control of the size and encapsulation capacity of amphotericin b, as well as optimizing physicochemical properties to promote stability in physiological media, increase bioavailability, provide site-specific distribution and reduce the toxicity. Polysorbate 80-coated amphotericin B-containing bovine albumin nanoparticles have a significant set of properties that make them an efficient nanocarrier model for the treatment of fungal infections in the central nervous system as they are surface coated with surfactant polysorbate 80, which has among its characteristics the ability to facilitate transport through the blood-brain barrier. In this context, the present invention aims to optimize the physicochemical properties by increasing the bioavailability and targeting in vivo of amphotericin b, in order to reduce the toxic effects contributing to treatment adherence for application in drug therapy of fungal infections. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113049727-A |
| priorityDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.