http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102017002678-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d7dc0431b7317ecccd046a5a50d385f |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62 |
| filingDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c05964f8217506fc83f681f0c8a49b4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50b17c4ffb8741e6dd583185132a87e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9836566d4373d202d349a4b077f4df48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_976f20723308c5846416bd955a3fc91f |
| publicationDate | 2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102017002678-A2 |
| titleOfInvention | process for obtaining bacteria with higher growth rate, biomass production and polyhydroxyalkanoate productivity by genetic engineering associated with adaptive evolution |
| abstract | Genetic Engineering Process for Obtaining Higher Growth Rate Bacteria, Biomass Production, and Polyhydroxyalkanoate Productivity Associated with Adaptive Evolution An innovative genetic engineering process associated with laboratory adaptive evolution is described for obtaining higher growth rate, higher bacterial strains. productivity of biomass and polyhydroxyalkanoates, specifically polyhydroxybutyrate (phb). This polymer has similar properties to plastic of petrochemical origin, but unlike these is easily biodegradable in the environment. The strategy was to express the gnd gene of the bacterium escherichia coli in the phb herbaspirillum seropedicae producing bacterium. however, as already reported for other organisms, gnd overexpression in h. seropedicae resulted in low growth. To circumvent such an effect, the overexpressing gnd bacterium has been evolutionarily adapted to support its overexpression. In the end, a new strain was isolated showing a 2.18-fold increase in phb productivity and 1.5-fold increase in phb yield by glucose consumed (yp; s). All mutations that occurred during evolutionary adaptation were identified. In that application, the use of such mutations in the development of organisms in general is claimed for processes comprising increasing the production of polyhydroxybutyrate and / or other metabolites of interest. |
| priorityDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 147.