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publicationDate 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-102016029220-A2
titleOfInvention ISOCUMARINE SYNTHESIS PROCESS USING REDUCED GRAPHEN OXIDE PALADIUM NANOParticles
abstract Isocoumarins are substances that have wide applicability in the medical field, this demand refers to the various studies based on their biological activity, since the main structure acts as a precursor for various products of commercial interest. However, isocoumarins are substances of natural origin, originating from fungi and plants, which makes their extraction impossible on a larger scale, given the low amount available. One of the novelties and advantages of this process is the use of heterogeneous catalysis using carbon supported pd, this facilitates the removal of the catalyst at the end of the process and its subsequent reuse. The present process utilizes nanoparticulate pd immobilized on chemically reduced graphene oxide. As a result, an optimal catalytic performance is obtained, with a yield between 78% and 84%, justified by the better uniformity of the nps distribution compared to the catalysts normally used.
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