| abstract |
The present invention relates to thirteen histone deacetylase inhibiting compounds, their synthesis process and their use as antitumor agents, pharmaceutical compositions, process for obtaining and using them. Most of the described compounds were synthesized in a few steps, even presenting a more complex chemical structure than vorinostat and santacruzamate a. Among the synthesized compounds, six have a pro-fluorophore group in their chemical structure, which makes them fluorescent under ultraviolet light (¿= 365 nm) and thus allows their use as biological probes to locate and unravel epigenetic mechanisms. |