| abstract |
adjuvant formulation containing essential oil of Brazilian red propolis and use in vaccine composition. Technical Sector: a61k 39/00, a61k 39/39, a61k 35/644 and a61k 39/05 The present invention relates to the provision of adjuvant formulations composed of red propolis essential oil (oepv) in its entirety or the use of its fractions alone or in combination to be used in the composition of vaccines for human or veterinary use. Within this inventive concept, protection of an immunogenic composition composed of rcp40 protein-associated oepv adjuvant to be used as a recombinant subunit vaccine for caseous lymphadenitis (lc) is also required. however adjuvant formulations containing oepv are not limited to use in lc vaccines, but may be used in the formulations of any vaccine against bacterial, viral, fungal, parasitic, neoplastic and allergic diseases. vaccines containing oepv adjuvant formulations are capable of inducing large increases levels of igg antibodies, and potentiate the cellular immune response, inducing a th1 profile, suitable for vaccines against intracellular, antineoplastic pathogens or even anti-allergic drugs. |