| abstract |
formulation containing monoterpene for the treatment of chronic pain, 80 male swiss mice (25 to 35 grams) aged 2 to 3 months were used to induce experimental fibromyalgia by injecting 20 µl of acid saline (ph = 4.0) into the gastrocnemius. . The animals were divided into groups and treated with vehicle (distilled water, vo), lim (50 mg / kg, vo) or lim-ßcd (50 mg / kg, vo) to evaluate the response time relationship and the possible anti-inflammatory effect. hyperalgesic. animals receiving lim-ßcd had an improvement in hyperalgesia until the eighth hour after treatment when compared with the control (p <0.001). It was also possible to observe that the group treated with lim-ßcd when compared to the lim isolated alone, obtained an increased response time with significant reduction of hyperalgesia (p <0.05 or p <0.001). A daily evaluation of the studied substance was also performed for a period of up to 7 days. In this case, it was observed that animals treated with lim-ßcd reduced the hyperalgesic condition until the last day of the experiment when compared to the control group, as well as the lim-ßcd group was better at reducing hyperalgesia when compared to the lim group. on every day of the experiment (p <0.001). |