http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102015027462-A2

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publicationDate 2017-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-102015027462-A2
titleOfInvention thermoreversible hydrogel nanoemulsion containing the essential oil of hyptis pectinata as analgesic
abstract heat-reversible hydrogel nanoemulsion containing the essential oil of hyptis pectinata as an analgesic. The present patent application relates to the production of the heat-reversible hydrogel containing the essential oil of hyptiss pectinata as an analgesic. Chronic pain is defined as pain lasting longer than tissue healing or pain lasting more than six months, such as fibromyalgia (flvl) and neuropathic pain. Musculoskeletal pain syndromes, such as FM, can be difficult to treat, which remains a major challenge for modern medicine. Thus, new studies have turned to medicinal plants as sources of new drugs, due to the various discoveries and scientific evidence about the beneficial effects of such plants. Due to its heat-sensitive property, in addition to being safe and capable of forming heat-reversible hydrogels and mucoadhesives in aqueous media, pluronic f12? has been used. In this way, the nanoemulsion of h oil was studied. , the secretion (neo-oil] -i) in heat-reversible hydrogel. Experimental protocols were performed in snussf mice, subcutaneously, in a volume of u, 3 ml, at a concentration of 3%, where long-lasting analgesic action can be observed on the non-inflammatory chronic muscle pain model. pharmacological action and effect on the central nervous system of ne-eoh.
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