http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102015018919-B1

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
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filingDate 2015-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43ad141e6f3dbfd24166d132b0196d1e
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publicationDate 2022-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-102015018919-B1
titleOfInvention Kit and method for testing dpd enzyme deficiency for patients being treated with fluoropyrimidines
abstract kit and method for testing dpd enzyme deficiency for patients being treated with fluoropyrimidines The present invention pertains to the technological sector of cancer chemotherapy and biochemical pharmacology and relates more specifically to a diagnostic test to determine the potential intolerance of a given patient to fluoropyrimidine class chemotherapy drugs. Composing the invention, there is the development of a kit for use in the dpd enzyme deficiency test, as well as a way of collecting, storing and transporting the sample of dry biological material on paper. the proposed kit allows the analysis of the toxicity of patients performing both saliva analysis. an individual risk rating is stipulated that the patient will present grades iii, iv and v toxicity in chemotherapy treatment with fluorpyrimidines. the advantages of the invention consist in the collection of only one biological sample to determine the concentrations of uracil (u) and dihydrouracil (uh2), as well as the stabilization of the concentrations of these dry substances on paper through the addition of gimeracil, which allows for non-refrigerated transport Sample.
priorityDate 2015-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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