http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102014011432-A8

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filingDate 2014-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19883df2976ef34531da06f650fec867
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46bd23340d4297c81ec5a3fc24e1a4ed
publicationDate 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-102014011432-A8
titleOfInvention three-dimensional framework for stem cells, process of obtaining it and its use
abstract three-dimensional framework for stem cells, process of obtaining it and its use. The present invention describes a three-dimensional biodegradable fibrin scaffold formed of a serinoprotease extracted from snake venom, a fibrinogen rich cryoprecipitate extracted from buffaloes, calcium chloride diluent and a solution of a stem cell population. The framework is suitable to support a population of 106 cells per ml of fibrin over an extended period of time, where stem cells are mesenchymal, umbilical tissue and mononuclear stem cells. The invention further describes the process of obtaining the framework, the components of which are provided separately and polymerized in situ after mixing. The described framework has numerous medical applications and may increase vascularization, cellular chemotaxis, nerve regeneration and / or wound healing at the site of administration. Due to their animal origin, there is no risk of transmitting infectious diseases.
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