process for the enzymatic synthesis of (7s) -3,4-dimethoxybicyclo [4,2,0] octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application to the synthesis of ivabradine and salts of same
process for the enzymatic synthesis of (7s) -3,4-dimethoxybicyclo [4.2.0] octa-1,3,5-triene-7-carboxylic acid or esters thereof and application in the synthesis of ivabradine and salts of same. A process for the enzymatic synthesis of the compound of formula (1): wherein R1 represents a hydrogen atom or an alkyl group. application in the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid.