http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102012020459-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_387013c8fe47396a7520a1eac70ac490 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K127-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K131-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K135-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-06 |
| filingDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6adee882decd88d45cdfb55f63897747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9343de9958b64b2f32e99c6adadcaaa3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa4139cea78590e60497a1e828c71435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50d973b369f7af38ea7eafaf8870dd98 |
| publicationDate | 2014-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102012020459-A2 |
| titleOfInvention | XANTHIUM CAVANILLESII VEGETABLE EXTRACT FOR STUDIES AS ANTIMALARIC |
| abstract | VEGETABLE EXTRACT OF XANTHIUM CAVANILLESII FOR STUDIES AS AN ANTIMALARIC. The present invention refers to the use of Xanthium cavanillesii extract for the purpose as an antimalarial, having as premise that studies in silico and in vitro corroborate the antimalarial activity of compounds present in this plant. A phytochemical study of X. cavanillesii was carried out in order to discover the antimalarial biological potential and the corresponding secondary metabolites. Thus extracts from the aerial parts of X. cavanillesii were obtained by maceration and tested against A. salina for toxicity using a mortality test. The ethanolic and aqueous extracts were tested in vitro against P. falciparum W ~ 2 ~ strains. The ethanolic extract showed activity superior to that compared to the aqueous extract, being then fractionated using the usual chromatographic methods (CC on silica and permeation on LH-20 sephadex gel). Analyzes of the fractions by HPLC, NMR ^ 1 ^ H and ^ 13 ^ C, EM, IV, allowed the characterization of ferulic, caffeic acids and a caurane diterpene, this compound was semipurified. Molecular anchorage studies were used to explain the mechanism of action against the PfATPase6 receptor model, with caffeic acid being more active. Thus, the elaboration of a patent for this extract is fundamental for the elaboration of a new pharmaceutical product with antimalarial properties. |
| priorityDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.