http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-102012019046-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_240e1cd00a69820e67a50d867333fd02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277 |
| filingDate | 2012-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcde1ffe4b08e593d03ede0e3bf4b26a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1a3ad780abc885539b0a2205114dc28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb7870c1a62f13e0c331f1800254d25e |
| publicationDate | 2020-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-102012019046-B1 |
| titleOfInvention | process of obtaining verapamil enantiomers in a conventional and unconventional simulated mobile bed |
| abstract | process of obtaining verapamil enantiomers in a conventional and unconventional simulated mobile bed. the present invention deals with a process of obtaining enantiomers of the drug verapamil by means of continuous chromatography in conventional and unconventional simulated moving bed. if, on the one hand, the enantiomers are currently separated only on an analytical scale, in a batch process, with a strictly pharmaceutical view, on the other hand, the present invention allows for an increase in scale in the production of the drug's enantiomers, making it possible to add commercial value to the product and the realization clinical trials in scientific research in the field with separate enantiomers. in addition, the commercialization of the drug, enantiomerically pure, will meet the requirements imposed by health regulatory agencies, with regard to the characterization of the pharmacokinetic and pharmacodynamic profiles of individual enantiomers. the present invention, using two different simulated moving bed techniques, allows to obtain the enantiomers with low operating cost and desirable productivity in a relatively short time scale when compared to the chromatographic process operated in batch mode, currently employed. it also makes it possible to reduce solvent consumption and increase the recovery of enantiomers per unit of chiral stationary phase mass used. |
| priorityDate | 2012-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.