| abstract |
"IMINO ACID DERIVATIVES AS METALOPROTEINASE MATRIX INHIBITORS". Ring-1-B-ring-2-D-ring-3-E-ring-4 The present invention relates to compounds of formula (1) are suitable for the preparation of medicaments for prophylaxis and therapy of diseases, the course of which is related to increased metalloproteinase matrix activity. These include diseases such as degenerative joint disease, for example osteoarthritis, spondylosis, cartilage loss following joint trauma or prolonged joint immobilization after meniscus or patella injury or ligament rupture, or connective tissue disease such as collagen, periodontal disease , healing disorders, or a chronic disease of the locomotor system such as acute or chronic, inflammatory, immune or metabolism-related arthritis, arthropathies, myalgias or disorders of bone metabolism or an ulceration, atherosclerosis or stenosis, or an inflammatory disease or carcinogenic disease, metastasis, cachexia, anorexia or septic shock. |