| abstract |
"K CHANNEL OPEN ACTIVATED BY LARGE CONDUCT CALCIUM". The present invention relates to a large conductance activated calcium K channel opener comprising a compound of formula (I): wherein ring A is a 5 membered heterocyclic ring containing any of O, N or S whose ring may be substituted by R 4, R 4 is R 5, aryl, heterocyclic or heterocyclic substituted carbonyl; R2 is hydrogen, halogen, carboxy, amino, alkyl, alkoxycarbonyl, alkenyl or cycloalkyl; R3 is aryl, heterocyclyl or alkyl; and R4 is hydrogen or alkyl, each of the substituents may be substituted, or a pharmaceutically acceptable salt thereof as an active ingredient. |