| abstract |
"Isoquinoline derivatives as matrix metalloproteinase inhibitors". The present invention relates to compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R 1, Q, Y, R 2, R 3, R 4, R 5, and n are as defined in the descriptive report as MMP-13 enzyme inhibitors. The invention also provides pharmaceutical compositions comprising a compound of Formula I, and the use of a compound of formula 1 for the manufacture of a medicament useful for the treatment of osteoarthritis and rheumatoid arthritis. |