| abstract |
"NUCLEOSIDE PHOSPHORILASE AND NUCLEOSIDASE INHIBITORS, COMPOSITIONS AND THEIR USES". The present invention relates to compounds of general formula (I) which are inhibitors of purine nucleoside phosphorylase (PNP), purine phosphoribosyltransferase (PPRT), 5'-methylthioadenosine phosphorylase (MTAP), 5'39 nucleosity > methylthioadenosine (MTAN) and / or nucleoside hydrolase (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoan infections and T-cell mediated disease and pharmaceutical compositions containing these compounds. |