| abstract |
"COMPOSITION, METHODS FOR PREPARING FACTOR VII STABLE POLYPEPTIDE, AND FOR TREATING FACTOR VII RESPONSIVE SYNDROME, AND USE OF FACTOR VII POLYPEPTIDE". The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII related polypeptide such that these compositions can be stored, manipulated and used at room temperature. The compositions comprise at least one stability agent selected from: a) a combination of an antioxidant and mannitol; b) a combination of a methionine and a polyol; c) a combination of a saccharide and mannitol; d) a combination of sucrose and a polyol; and e) methionine. The antioxidant is, for example, homocysteine, cysteine, cystathionine, methionine or glutathione. The saccharide is, for example, sucrose, dextrosel, lactose, maltose, trehalose, cyclodextrins, maltodextrins or dextrans. The polyol is, for example, mannitol, sorbitol or xylitol. |