| titleOfInvention |
A compound or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical composition, and methods for treating hyperglycemia, diabetes or insulin resistance, for treating non-insulin dependent diabetes mellitus, for treating obesity, for treating syndrome x, for treating a lipid disorder selected from the group consisting of dyslipdemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low hdl and high ldl, and to treat atherosclerosis in a mammalian patient in need of such treatment. |
| abstract |
"COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVAT, PHARMACEUTICAL COMPOSITION, AND METHODS FOR HYPERGLYCEMIA, DIABETES OR RESISTANCE TO INSULIN, TO TREATE DIABETARY DIABETARY, INTARBUS DIABETES, SELECTED LIPID FROM THE GROUP CONSISTING OF DYSLIPIDEMIA, HYPERLIPIDEMIA, HYPERTRIGLYCERIDEMIA, HYPERCOLESTEROLEMIA, LOW HDL AND HIGH LDL, AND TO TREAT ATHEROSCLEROSIS IN A MAMMAL PATIENT IN THE NEED OF TREATMENT. Compounds having Formula (I): including pharmaceutically acceptable salts, hydrates and solvates thereof, are selective inhibitors of the 11β-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as non-insulin dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM. |