| abstract |
"COMPOUNDS; PHARMACEUTICAL COMPOSITIONS FOR ADMINISTRATION IN A MAMMER AND METHODS FOR INHIBITING THE CYTOCHROME P450RAI ENZYME". Compounds of formula (I) in which the variables are defined in the descriptive report, which have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for the treatment of mammals with retinoid-treatable conditions are described. are controlled by or responsive to the body's native retinoic acid. Formulations containing the compounds of the invention may also be administered with retinoids and / or vitamin A to enhance or prolong the effects of retinoid-containing medications, vitamin A, or the organism's native retinoic acid. |