| abstract |
"DIABETES TREATMENT METHODS USING PDE11A INHIBITORS". The present invention relates to methods of treating diabetes, particularly type 2 diabetes, and related disorders by administration of a PDE11A inhibitor. Such PDE11A inhibitors may be administered in combination with alpha-glucosidase inhibitors, insulin sensitizers, insulin secretagogues, hepatic glucose-lowering compounds, beta3 agonist or insulin. Such PDE11A inhibitors may also be administered in combination with body weight reducing agents. Other methods of the invention relate to stimulation of insulin release from pancreatic cells, particularly in response to an elevation in blood glucose concentration, by administration of a PDE11A inhibitor. |