| abstract |
"PROCESS FOR MANUFACTURING CHIRAL 1,4-DISSUBSTED PIPERAZINES". The present invention relates to a process for the stereoselective preparation of novel chiral nitrogen mustard derivatives useful in the synthesis of optically active 1,4-disubstituted piperazines of formula (I) wherein R, Ar, and Q are defined as shown herein. and intermediate compounds therefor. 1,4-Disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders. |