| abstract |
"2-PYRIDINYL AND 2-PYRIMIDINYL-6,7,8,9-TETRAHYDRO-PYRIMED [1,2-AIPYRIMIDIN-4-ONLY HYDERO-ARYLA SUBSIDIATES". The present invention relates to a pyrimidone derivative represented by formula (1) or a salt thereof wherein: (1) X represents two hydrogen atoms, one sulfur atom, one oxygen atom or a C 1-1 alkyl group. 2 is a hydrogen atom; Y represents a bond, an ethenylene group, an ethinylene group, or an optionally substituted methylene group; R 1 represents a 2, 3 or 4-pyridine ring or an optionally substituted 2, 4 or 5-pyrimidine ring; R2 represents a heterocyclic bicyclic ring having 1-4 heteroatoms selected from an oxygen atom, a sulfur atom and a nitrogen atom and having 5-9 carbon atoms of formula (II) R3 represents a hydrogen atom, a C 1-6 alkyl group, a hydroxy group, a C 1-4 alkoxy group or a halogen atom; R 4 represents a hydrogen atom, a C 1-6 alkyl group, a C 1-4 alkoxy group or a halogen atom. The invention also relates to a medicament comprising said derivative or salt thereof as an active ingredient which is used for the preventive and / or therapeutic treatment of a neurodegenerative disease caused by abnormal GSK3? Or GSK3? Activity and cdk5 / p25, such as Alzheimer's disease. |