| abstract |
"COMPOSITION, PHARMACOLOGICALLY ACCEPTABLE ESTER OF THE SAME, PHARMACEUTICAL COMPOSITION AND METHODS FOR PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASES, RHEUMATIOUS ARTHRITIS AND REJECTION CAUSED BY THE ORGANIC TRANSPLANTATION." The present invention relates to alcohol amine derivatives or phosphonic acid derivatives having excellent immunosuppressive activity, pharmaceutically acceptable salts thereof or pharmacologically acceptable esters thereof, and pharmaceutical compositions comprising said compounds as an active ingredient: R 2 and R 2 each represent a hydrogen atom or an amino group protecting group; R3 represents a hydrogen atom or a hydroxyl protecting group; R4 is a lower alkyl group; n represents an integer from 1 to 6; X represents an oxygen atom or a nitrogen atom unsubstituted or substituted with a lower alkyl group or the like; Y represents an ethylene group; Z represents a C1 -C10 alkylene group; R 5 represents an aryl group or a substituent substituted aryl group; R 6 and R 7 each represent a hydrogen atom; provided that when R5 represents a hydrogen atom, then Z represents a group other than a single bond or a straight-chain C1 -C10 alkylene group]. |