http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0306656-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3873abaff397acbfffa1595a12cfef41 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-998 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0676 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2003-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61fbd596d8b544b0f1f5ca99dfd23c76 |
| publicationDate | 2004-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0306656-A |
| titleOfInvention | Transdifferentiation of acinar pancreatic cells |
| abstract | "TRANSDIFERENCING ACINARY PANCREATIC CELLS". Induction of <225> cell neogenesis has been associated with ductal epithelium, however <sym> 80% of the pancreas is composed of acinar cells. Surprisingly, acinar pancreatic cells contribute to the <225> cell neogenesis. Pancreatic partial duct obstruction (PDO) is a known inducer of <225> cell neogenesis leading to expansion of <225> cell mass and the effect appears to be mediated by INGAP, an acinar cell protein originally identified in regenerated hamster pancreas. We examined the effects of PDO on the incorporation of tritiated thymidine by acinar cells and pancreatic β-cells in female Syrian hamsters. A single dose of tritiated thymidine was administered to all animals two weeks after PDO. The animals were then sacrificed at 1 hour, or at six weeks after injection. Thymidine incorporation into acinar cells was greater at 2 weeks after PDO and was reduced at 8 weeks after PDO. The incorporation of tritiated thymidine into β-cells was inversely related to what was observed in acinar cells. Two weeks after PDO, uptake of tritiated β-cell thymidine was relatively slow and increased significantly at 8 weeks after PDO, according to the neogenesis of acinar-cell-derived <225> cell. Electron microscopy demonstrated cells with zymogen granules and endocrine granules, also suggesting endocrine acinar cell transdifferentiation. In a second experiment, hamsters received either an INGAP protein pentadecapeptide or an equivalent volume of saline for 10 days. A double increase in the number of extra-islet acinar-associated β-cell chains occurred in INGAP peptide-treated hamsters resulting in a 2.8-fold increase in β-cell mass. Differentiation of acinar cells into <225> cells provides an alternative pathway for <225> cell neogenesis; INGAP peptide plays a significant role in this process. |
| priorityDate | 2002-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.