http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0303790-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9053336f864c5a26dbb215cf18470db1 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2003-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_298d23639d2a444b0a5135c18a8efbeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8646da25d0bb2a915634c7bc451a46b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30c7d7206b2b36a8ab98076f14c42c1d |
| publicationDate | 2004-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0303790-A |
| titleOfInvention | Processes for obtaining 2-chloro-1- (4-chlorophenyl) -1-ethanone by reacting 4-chloroacetophenone with meta-chloroperbenzoic acid (mcpba) from (r) - (-) - 2-halo 1- (4-chlorophenyl) -1-ethanols by bioreduction with rhodotorula glutinis cct 2182 or any mutant thereof and - (+) - 2-halo-1- (4-chlorophenyl) -1-ethanols by bioreduction with geotrichum candidum cct 1205 or any mutant thereof, chiral percusors for obtaining the enantiometers of the drug eliprodil and its derived salts |
| abstract | "PROCEDURES FOR OBTAINING 2-CHLORO-1- (4-CHLOROPHENYL) -1-ETHANONE THROUGH THE REACTION OF 4-CHLOROKETOPHENONE (MCPBA) FROM (R) (-) - 2-HALO- 1- (4-CHLOROPHENYL) -1-ETHANOLS BY BIODREDUCTION WITH RHODOTORULA GLUTINIS CCT 2182 OR ANY MUTANT, HER DERIVED AND (S) - (+) - 2-HALO-1- (4-CHLOROPHENYL) -2-ETHANOLS BY BIORREDUCTION WITH GEOTRICHUM CANDIDUM CCT 1205 OR ANY MUTANT DERIVED FROM THIS, CHIENT PRECURSORS FOR OBTAINING ELIPRODIL'S ENANTIMER AND ITS DERIVED SALTS. " The present invention relates to the preparation of 2-chloro-1- (4-chlorophenyl) -1-ethanone by reacting 4-chloro-acetophenone with MCPBA of (R) - (-) - 2-halo 1- (4-chlorophenyl) -1-ethanols by bioreduction with Rhodotorula glutinis CCT 2182 and (S) - (+) - 2-halo-1- (4-chlorophenyl) -1-ethanols by bioreduction with Geotrichum candidum CCT 1205, precursors chiral salts to obtain the enantiomers of the drug Eliprodil and its derived salts; deals with the preparation of 2-chloro-1- (4-chlorophenyl) -1-ethanone by reacting 4-chloroacetophenone with MCPBA from (R) - (-) - 2-halo-1- (4-chlorophenyl) -1-ethanols by bioreduction with Rhodotorula glutinis CCT 2182 and (S) - (+) - 2-halo-1- (4-chlorophenyl) -1-ethanols by bioreduction with Geotrichum candidum CCT 1205, chiral precursors for obtaining enantiomers Eliprodil and its salts thereof; deals with a 2-chloro-1- (4-chlorophenyl) -1-ethanone preparation process by reacting 4-chloroacetophenone with meta-chloroperbenzoic acid (MCPBA) in quantitative yield of (R) - (- ) -2-halo-1- (4-chlorophenyl) -1-ethanols and (S) - (+) - 2-halo-1- (4-chlorophenyl) -1-ethanols in high chemical and enantioselective yield using Rhodotorula glutinis CCT 2182 and Geotrichum candidum CCT 1205 cells in growth medium and their applications for the preparation of Eliprodil enantiomers; and comprises the preparation of 2-chloro1- (4-chlorophenyl) -1-ethanone, in quantitative yield, the bioreduction of 2-chloro-1- (4-chlorophenyl) -1-ethanone and 2-bromo-1- ( 4-chlorophenyl) -1-ethanone (commercial product) to obtain (R) (-) - 2-halo-1- (4-chlorophenyl) -1-ethanols, with 95-97% chemical yield and an excess > 99% enantiomer using Rhodotorula glutinis CCT 2182 yeast in growth medium, and also by adsorption of 2-halo-1- (4-chlorophenyl) -1-ethanones on Amberlite XAD-7 resin followed by bioreduction by Rhodotorula glutinis CCT 2182 in growth medium to obtain (R) - (-) - 2-halo-1- (4-chlorophenyl) -1-ethanols, with 95% chemical yield and> 99% enantiomeric excess. Bioreduction of 2-halo-1- (4-chlorophenyl) -1-ethanones to obtain (S) - (+) - 2-halo-1- (4-chlorophenyl) -1-ethanols, with chemical yield of 95% and> 99% enantiomeric excess using Geotrichum candidum CCT 1205 yeast and also by adsorption of 2-halo-1- (4-chlorophenyl) -1-ethanones on Amberlite XAD-7 resin followed by bioreduction by Geotrichum candidum CCT 1205 in growth medium to obtain (S) - (+) - 2-halo-1- (4-chlorophenyl) -1-ethanols, with 95% chemical yield and> 99% enantiomeric excess. |
| priorityDate | 2003-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.