| abstract |
"COMPOUND, PHARMACEUTICAL FORMULATION, USE OF A COMPOUND, DISEASE TREATMENT METHOD, AND PROCESS FOR PREPARING A COMPOUND". The present invention relates to compounds of formula (I), and to pharmaceutically acceptable salts thereof, prodrugs, solvates and crystalline forms thereof, wherein R 1 and R 2 independently represent: an alkyl group C 1-6 ~; an optionally substituted C 1-1 -C 4 (amino) alkyl group; an optionally substituted non-aromatic C 3-12 carbocyclic group; a (C 3-12 cycloalkyl) C 1-3 alkyl group; a group (CH ~ 2 ~) ~ r ~ (phenyl) ~ s ~, where r is 0, 1, 2, 3 or 4, s is 1 when r is 0 or otherwise s is 1 or 2 and the phenyl groups are optionally independently substituted by Z; naphthyl; anthracenyl; an optionally substituted saturated 5- to 8-membered heterocyclic group containing one nitrogen and optionally one of the following: oxygen, sulfur or an additional nitrogen; 1-adamantyl methyl; a - ((CH 2 -) - t -, Het group, where t is 0, 1, 2, 3 or 4, and the alkylene chain is optionally substituted and Het represents an optionally substituted aromatic heterocycle; ^ represents H and R ^ 2 ^ is as defined above, or R ^ 1 ^ and R ^ 2 ^, together with the nitrogen atom to which they are attached, represent an optionally substituted saturated 5- to 8-membered heterocyclic group as above X is CO OR SO-2 Y is absent or represents NH optionally substituted by a C 1-3 alkyl group, R 3 and R 4 independently represent phenyl, thienyl or Z-substituted pyridyl; Z represents a C 1-3 1-3 alkyl group, a C 1-3 1-3 alkoxy group, hydroxy, halo, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, trifluoromethylsulfoyl, nitro, amino, mono or di-C 1-3 alkylcarbamoyl, sulfamoyl and acetyl, and R5 is H, a C1-3 alkyl group, C1-3 alkoxymethyl group, trifluoromethyl, C1-3 hydroxyalkyl group, C1-3 alkoxycarbonyl group 1-3C, carboxy, cyano, carbamoyl, mono- or di-C 1-3 alkylcarbamoyl, acetyl or hydrazinocarbonyl of the formula; with the conditions; and processes for the preparation of such compounds, their use for the treatment of obesity, psychiatric and neurological disorders, methods for their therapeutic use, and pharmaceutical compositions containing them. |