| abstract |
"Compost, a method of treating a patient who has or should prevent a patient from acquiring a disease or condition, and a method of producing a compound." The invention relates to substituted piperidine piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds which are capable of inhibiting beta-secretase, an enzyme that cleaves the amyloid precursor protein to produce amyloid beta peptide. (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. |