| abstract |
"USEFUL SPYROHYDANTOINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS". Compounds having formula (I) and pharmaceutically acceptable salts, hydrates, enantiomers and diastereoisomers and their promulgations, (i) are useful as inhibitors of LFA-1 / ICAM and as anti-inflammatory agents, wherein L and K is O or S; Z is N or CR ~ 4b ~; Ar is an optionally substituted aryl or heteroaryl; G is a linker linked to T or M, or is missing; J, M and T are selected to define a saturated or partially unsaturated three to six membered non-aromatic ring; and R ~ 2 ~, R ~ 4a ~, R ~ 4b ~ and R ~ 4c ~ are as defined in the specification. |