| abstract |
"Spirited Compounds". The present invention relates to compounds of formula (I): wherein: A is an optionally substituted straight chain hydrocarbon having from 1 to 6 carbon atoms, which is optionally interposed by oxygen or nitrogen; Ar1 is aryl or heteroaryl, any of which being optionally substituted; n is 0 or 1; R4 O4 is hydrogen or lower alkylene attached to a position of A which may be arbitrarily bonded; - T, U, V and W independently represent an optionally substituted nitrogen or methane atom and at least two of T, U, V and W represent said methane group; - X is -N (SO-2-R4) -, -N (COR-2 ^) - or -CO-; - Y is -C (R 3 R 4) (R 4 R 4) -, -O- or -N (R 5 R 5) -; - Z is methane or a nitrogen atom, wherein said compounds exhibit NPY antagonistic activities and are useful as agents for the treatment of various NPY-related diseases, eg cardiovascular disorders such as hypertension, nephropathy, heart disease. , vessel spasms, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, apprehension, epilepsy, dementia, pain, alcoholism, feeling of drug-free, circadian rhythm disorders, schizophrenia, etc. , metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, etc., sexual and reproductive dysfunction, and gastrointestinal mobility disorders. |