| abstract |
"TIENOPYRIMIDINDIONS AND ITS USE IN MODULATING AUTOIMMUNE DISEASES". The present invention relates to a compound of formula (1): wherein: R 1 and R 2 each independently represent a C 1-6 alkyl group, C 3-6 alkenyl group. C 3-6 cycloalkyl, C 1-3 alkyl or C 3-6 cycloalkyl; each of which may optionally be substituted by 1 to 3 halogen atoms; R3 is isoxizolidin-2-ylcarbonyl or tetraisoxazin-n-2ylcarbonyl, where each ring is optionally substituted by a hydroxy group; - Q is CO or C (R ^ 4 ^) (R ^ 5 ^), where R ^ 4 ^ is a hydrogen atom or C 1-4-alkyl and R ^ 5 ^ is a hydrogen atom or a group. hydroxy; - Air is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulfur, the ring system being optionally substituted by one or more substituents as defined in the report. descriptive. The invention also relates to methods of preparation, pharmaceutical compositions containing the compound of formula (1) and methods of using such a compound, particularly for modulating autoimmune diseases. |