| abstract |
"N-ARYLPHENYLACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME". N-Arylphenylacetamide derivatives represented by the following formula [I]: (wherein R4 is alkoxy of C 1-6, etc.; R4 is hydrogen, - (CH2 -) - m ~ -N (R ^ 6 ^) (R ^ 7 ^) (m is an integer from 1 to 4; R ^ 6 ^ is hydrogen, C 1-4 alkyl, etc., R ^ 7 ^ is hydrogen , etc.), etc .; R4 is hydrogen, halogen, etc. R4 is R6-10 alkyl, -YR4 R8 (Y is a single bond, C1-6 alkylene. 1-6, C 2-6 alkenylene, C 2-15 alkynylene, etc. R 5 is aryl, C 3-8 cycloalkyl, C 6-15 polycycloalkyl , etc.), etc .; R 5 is hydrogen, etc. and X 12 is hydrogen), or pharmaceutically acceptable salts thereof or hydrates or solvates thereof, and a pharmaceutical composition containing them. These compounds are useful as preventives and / or remedies giving no pain at the initial stage of administration which are effective in oral administration and have potent analgesic and anti-inflammatory effects. |