| abstract |
"LARGE CONDUCTANCE CALCULATED K CHANNEL OPENER". A high-conductance calcium-activated K-channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): wherein X represents NR ^ 4 ^, O or S, R 1 and R 2 each independently represent hydrogen, halogen, carboxyl group, amino, lower alkyl, lower alkoxycarbonyl, lower alkenyl, lower cycloalkyl, carbamoyl, aryl, heterocyclic or heterocyclic-substituted carbonyl, R R3 represents aryl, heterocyclic or lower alkyl group, and R4 represents hydrogen or lower alkyl group. |