http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0207486-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| filingDate | 2002-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8696f82721391a60609103a986e68463 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec991efeffd1c4f1ca957ca26c9720f3 |
| publicationDate | 2006-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0207486-A |
| titleOfInvention | Method of treating insulin resistance or hypoinsulinemia in mammals, method of detecting the presence or onset of insulin resistance or hypoinsulinemia in mammals, insulin resistance or hypoinsulinemia treatment kit, hybridoma, antibody, method of treating obesity or hypoinsulinemia in mammals, method for detecting the presence or onset of obesity or hyperinsulinemia in mammals, obesity or hyperinsulinemia treatment kit, diagnostic kit for detecting the presence or onset of insulin resistance, hyperinsulinemia or obesity, method of repairing or regenerating muscles in mammals, muscle repair or regeneration kit, monoclonal antibody preparation, method of assessing the effect of a possible pharmaceutical drug on insulin resistance, hypoinsulinemia or muscle repair, method of assessing the effect of a possible pharmaceutical drug on obesity or hyperinsulin emia, non-human transgenic animal, use of dickkopf-1 antagonist, use of dickkopf-1 (dkk-1) and use of a possible pharmaceutical drug |
| abstract | "METHOD OF TREATING INSULIN RESISTANCE OR HYPOINSULINEMIA IN HAMMERS, METHOD OF DETECTION OF THE PRESENCE OF OR INSULIN RESISTANCE TO HYMPOSININIA IN MAMMALS, METHOD OF DETECTION OF PRESENCE OR BEGINNING OF OBESITY OR HYPERINSULINEMIA IN MAMMALS, KIT OF OBESITY OR HYPERINSULINEMIA, DIAGNOSTIC KIT FOR DETECTION OR INSULATION OF RESISTANCE OR HYPERINSULINEMIA MUSCLE MUSCLES, MUSCULAR REPAIR OR MUSCLE REPAIR KIT, PREPARATION OF MONOCLONAL ANTIBODY, METHOD OF EVALUATION OF A POSSIBLE PHARMACEUTICAL DRUG ON MUSCULAR INSULIN RESISTANCE OR MUSCULAR DYESULINUS RESPONSE OBESID ADE OR HYPERINSULINEMIA, NON-HUMAN TRANSGENIC ANIMAL, USE OF AN ANTAGONIST FOR DICKKOPF-1 (Dkk-1), USE OF E AND DICKKOPF-1 (Dkk-1) AND USE OF A POSSIBLE PHARMACEUTICAL DRUG ". Dickkopf-1 (Dkk-1) protein antagonists are administered in effective amounts for the treatment of disorders involving insulin resistance, such as nondependent insulin diabetes mellitus (NIDDM). hypoinsulinemia and dysfunctions involving muscle atrophy, trauma or degeneration. Preferably, antagonists are composed of compositions comprising antibodies directed to Dkk-1 in a pharmaceutically acceptable carrier for use in blocking the effects of Dkk-1. Additionally, a method of treating obesity or hyperinsulinemia in mammals is provided by administering an effective amount of Dkk-1 to mammals. Methods of diagnosing insulin resistance, hyper and hypoinsulinemia, obesity, and related dysfunctions using Dkk-1 as a target and non-human transgenic animals that overexpress dkk-1 nucleic acid are also provided. |
| priorityDate | 2001-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.