| abstract |
"6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOEPTENYL ACTILED AMINES AND THEIR USE AS A PHARMACEUTICAL AGENT". The present invention relates to compounds according to the general formula (I) where R 1 R 2 -R 4 R 4 have the same meanings given in the description, A is CH 2 -, CHOH or CH (C 1 - 1). (C 3 -alkyl), B, C and D are independently CH 2 or CH- (C 1 -C 3 -alkyl), and R 5 is an aryl or heteroaryl group, possibly replaced by the substituents listed in the description. These compounds are useful for the manufacture of medicaments for the treatment of cardiovascular disease, stable or unstable angina pectoris, coronary heart disease, Prinzmetal angina, acute coronary syndrome, cardiac arrest, myocardial infarction, stroke, thrombosis, peripheral arterial occlusive disease, endothelial dysfunction, atherosclerosis, restenosis, endothelial damage after PTCA, hypertension, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular hypertension, chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, diabetes, complications of diabetes, nephropathy, retinopathy, angiogenesis, asthmatic bronchitis , chronic renal failure, liver cirrhosis, osteoporosis, or restricted memory performance or for a restricted ability to learn, or for decreasing cardiovascular risk in postmenopausal women or after taking contraceptives. |