http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0204026-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_093c3b590d376f99c696d42c8a6492b7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef0113f1697f888380195af2fd132559 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ef886b784415fd57b50300d994817c7 |
| publicationDate | 2003-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0204026-A |
| titleOfInvention | Use of kielmeyera coriacea plant extract and its active principles for the treatment of depression systems, associated or not with anxiety disorders |
| abstract | "USE OF THE KIELMEYERA CORIACEA PLANT EXTRACT AND ITS ACTIVE PRINCIPLES FOR THE TREATMENT OF DEPRESSION SYMPTOMS, ASSOCIATED OR NOT WITH ANXIETY DISORDERS". Consisting of the standardized extract of the plant Kielmeyera coriacea, or its active ingredients for the treatment of depression, as well as for the control of symptoms arising from depressive disorders. Hydroalcoholic extract of this plant administered for 45 days orally has been shown to inhibit the immobility of rats in the forced swim test with imipramine-like efficacy (Figure 1) without altering locomotor activity (Figure 2). In addition, Kielmeyera coriacea extract inhibited uptake of [^ 3 ^ H] dopamine, [^ 3 ^ H] serotonin and [^ 3 ^ H] noradrenaline in rat brain synaptosomes (Figures 3, 4 and 5). . Finally, compounds isolated by fractionation of Kielmeyera coriacea, dichloromethane and ethyl acetate inhibited the immobility of animals in the forced swim in rats with nortriptyline-like efficacy (Figure 6), without altering locomotor activity (Figure 7). The invention relates to the use of the standardized Kielmeyera coriacea plant extract or its active principles in the treatment of depressive states, as well as for the control of symptoms arising from depressive disorders. |
| priorityDate | 2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.