abstract |
"UREA AND URETANE DERIVATIVES AS INTEGRINE INHIBITORS". The present invention relates to novel urea and urethane derivatives of the generic formula (I) wherein R 1, R 2, R 3, R 5, R 5, X, Y , B, m, neo are as defined in claim 1, and their physiologically acceptable salts or solvates, which are integrin inhibitors and may be employed to combat thrombosis, heart infarction, coronary disease, arteriosclerosis, inflammation, tumors, osteoporosis, infections and restenosis after angioplasty, or in pathological processes maintained or propagated by angiogenesis. |