| abstract |
"CARBOXAMIDE DERIVATIVES AND ITS USE IN TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMORS". The present invention relates to compounds of formula (I), wherein the variables have the following meaning, D is phenyl or pyridyl, each of which is unsubstituted or monosubstituted or polysubstituted by Hal, A, OR2,. N (R ^ 2 ^) -2 ~, NO ~ 2 ~, CN, COOR ^ 2 ^ or CON (R ^ 2 ^) ~ 2 ~; R3 is H, Ar, Het, cycloalkyl or A, which may be substituted by OR2, R3, N (R2, 2) -2, Ar, Het, cycloalkyl, CN, COOR. ^ 2 ^ or CON (R ^ 2 ^) ~ 2 ~; R2 is H or A; E is phenylene which may be monosubstituted or polysubstituted by Hal, A, OR ^ 2 ^, N (R ^ 2 ^) ~ 2 ~, NO-2 ~, CN, COOR ^ 2 ^ or CON (R ^ 2 ^) -2, or is piperidino-1,4-diyl; W is Ar, Het or N (R 2 R 2) -2 and, if E = piperidine-1,4-diyl, is alternatively R 2 R 2 or cycloalkyl, X is NH or O, are coagulation factor inhibitors They may be employed for the prophylaxis and / or therapy of thromboembolic diseases and for the treatment of tumors. |