| abstract |
"USE OF 5-HT ~ 1A ~ AGONISTS AND COMBINED SELECTIVE SERTONINE RECAPTATION INHIBITORS". The present invention relates to the use of compounds, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and 5-HT-1A-receptor agonists being combined, in particular 1- [4- (5- cyanoindol-3-yl) butyl] -4- (2-carbamoyl-benzofuran-5-yl) -piperazine or a physiologically acceptable salt thereof or 3- {4- [4- (4-cyano-phenyl) -piperazin-1 -yl] -butyl} -1H-indol-5-carbonitrile or a physiologically acceptable salt thereof, for the manufacture of a medicament for the treatment of chronic pain disorders or in the treatment of other conditions where there is hypersensitivity to painful signs, hyperalgesia, allodynia, increased pain perception, and increased pain memory, as well as for the treatment of irritable bowel syndrome (IBS). |