http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-0115393-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2001-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1de1ede11d052d5f921eec15214131d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ad1b2940213e774425c7985b808573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_571a56049700f9445fe2bc753adf02d4 |
| publicationDate | 2004-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-0115393-A |
| titleOfInvention | Benzodiazepine derivatives as gaba receptor modulators |
| abstract | "BENZODIAZEPIN DERIVATIVES AS GABA A RECEPTOR MODULATORS". The present invention relates to compounds of formula (I) wherein R1 is hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, cyano, trifluoromethyl, trifluoromethoxy, or lower alkylthio; R2 is C (O) O-lower alkyl, isoxazole, 1,2,4-oxadiazol-3-yl or 1,2,4-oxadiazol-5-yl, whose rings may be substituted by lower alkyl, trifluoromethyl or cycloalkyl; R3 is hydrogen, lower alkyl, - (CH2-) ~ n -cycloalkyl, - (CH2-) ~ n -halogen, - (CH2-) ~ n-pyridin-4 -yl, or - (CH ~ 2 ~) ~ n ~ -phenyl, where the phenyl ring may be substituted by one or two substituents selected from the group consisting of lower alkoxy, halogen, -SO ~ 2 ~ CH ~ 3 ~, phenyl, OCF ~ 3 ~, nitro, CF ~ 3 ~, -NR ~ 2 ~, or is (CH ~ 2 ~) ~ n -indole, optionally substituted by lower alkyl or lower alkoxy, or is pyrrolidinyl-5 -oxo, -C (O) -NR ~ 2 ~, - (CH ~ 2 ~) ~ n ~ OH, - (CH ~ 2 ~) ~ n ~ -NR ~ 2 ~ or - (CH ~ 2 ~) ~ n-benzo [1,3] dioxol; R is hydrogen or lower alkyl; e is 0, 1, 2 or 3; and their pharmaceutically acceptable acid addition salts, with the exception of the following compounds: 9H-imidazo [1,5-a] [1,2,4] triazolo [3,4-d] [1,4] benzodiazepine-10 -ethylcarbylate, 10- (3-cyclopropyl-1,2,4-oxadiazol-5-yl) -9H-imidazo [1,5-a] [1,2,4] triazolo [4,3-d ] [1,4] benzodiazepine, ethyl 3-fluoro-9H-imidazo [1,5-a] [1,2,4] triazolo [3,4-d] [1,4] benzodiazepine-10-carboxylate, 10- (3-cyclopropyl-1,2,4-oxadiazo [-5-yl) -3-fluoro-9H-imidazo [1,5a] [1,2,4] triazolo [3,4-d] [ 1,4] benzodiazepine, ethyl 3-chloro-9H-imidazo [1,5-a] [1,2,4] triazolo [3,4-d] [1,4] benzodiazepine-10-carboxylate and 3 -chloro-10- (3-cyclopropyl-1,2,4-oxadiazol-5-yl) -9H-imidazo [1,5a] [1,2,4] triazolo [3,4-d] [1, 4] benzodiazepine. Such compounds have good affinity for GABA A? 5 receptors and are therefore useful for treating diseases related to this receptor. |
| priorityDate | 2000-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.