| abstract |
"METHODS FOR MODULATING THE BLADDER FUNCTION". This invention provides methods and pharmaceutical compositions for maintaining bladder control or treating urinary incontinence in a mammal using KCNQ potassium channel agonists, including KCNQ2, KCNQ3, KCNQ4 and KCNQ5 potassium channels alone or in combination. Compounds useful in such methods include 1,2,4-triaminobenzene derivatives described in US Patent No. 5,384,330 (Dieter et al.) And the 3-phenyl oxindole compounds described in US Patent No. 5,565. 483 (Hewawasam and others). Preferred compounds of this invention include N- [2-amino-4- (4-fluorobenzylamino) phenyl] carbamic acid ethyl ester, also referred to as retigabine. |